Because the vitamin is water-soluble, excess amounts of it will be eliminated
intracellular half-life is prolonged because of lysosomal release and cytosolic resequestration, creating a depot effect that supports monthly maintenance dosing for chronic deficiencies
Reduced Inflammation: Preliminary data suggests it may modulate inflammatory responses, potentially aiding in chronic pain management and faster healing
In renal impairment, this axis contributes to a feedback loop driven by gut dysbiosis, systemic inflammation, oxidative stress, blood pressure dysregulations, and neurocognitive decline (Bugnicourt et al., 2013
Thiosulfate infusions also decrease cyanide toxicity but can cause accumulation of thiocyanate resulting in clinical toxicity