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The three receptors targeted by retatrutide are: GLP-1R (Glucagon-like peptide-1 receptor) a well-established target already exploited by approved medicines such as semaglutide and liraglutide GIPR (Glucose-dependent insulinotropic polypeptide receptor) also targeted by tirzepatide in combination with GLP-1R GCGR (Glucagon receptor) an additional target that distinguishes retatrutide from currently approved dual agonists This triple mechanism of action places retatrutide in a distinct pharmacological class

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The next step was to try to combine all three hormones, GLP-1, glucagon and GIP

Based on the monthly dosing efficacy and tolerability demonstrated in this trial, we remain confident in our plan to include a higher 9.6-milligram monthly maintenance dose of PF3944 in Phase 3. The drug was made by developer Metsera, which Pfizer acquired in a bidding war with competitor Novo Nordisk last year