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If confidence in this approach depends on the belief that it has already been studied at scale, that belief is not supported by current evidence

In this trial, patients received NA starting with 250 mg750 or 1000 mg per day over a course of four months, with the last follow-up 10 months later

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In diabetic kidney disease patients, a reduction in insulin levels, albuminuria, and the progression of renal failure were observed as a GLP-1R effect [56, 57]