159 If symptoms continue despite these measures, dose de-escalation is considered because the incidence and severity of adverse effects are dose-dependent, with higher doses associated with a higher incidence and severity of complaints
TMAO is odorless, but individuals with reduced FMO3 enzyme activity (the enzyme responsible for TMA oxidation) excrete unmetabolized TMA through sweat and breath, producing the characteristic odor
The medication provides a window of opportunity to learn portion control, make better food choices, and establish an exercise routine
They use the first few weeks from a vial reconstituted at lower concentration (5 mL water for 2 mg/mL) for the early phases when precision matters most
Socaa K, Szopa A, Serefko A, Poleszak E, Wla P