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The samples were then immersed in PBS with 0.02% sodium azide (Sigma-Aldrich) at 4 C until sectioning

Pretorius E, Venter C, Laubscher GJ, Kotze MJ, Oladejo SO, Watson LR, et al

9 GSH can be depleted intracellularly either by forming a direct complex with an electrophilic agent (accomplished investigationally by agents such as bromobenzene or diethyl maleate) via inhibition of synthesis, or by subjecting cells to oxidant stress

Critical Safety Considerations for Thyroid Patients on GLP-1 Therapy GLP-1 medications slow stomach emptying, which can delay the absorption of levothyroxine (the most common thyroid replacement hormone)

With respect to desensitization, all those data support the idea that agonists are able to promote a different regulation of OR as demonstrated for other GPCR such as the histamine H2 receptors (Alonso et al., 2014)