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Endocrinology (2003) 144(12):514958

Key advancements in peptide technology for triple receptor agonism: Application of computational modeling to peptide-receptor binding Fatty acid substitution for extended stability and duration -helical design for superior receptor fit Structure-based design to hone drug action and safety Engineering peptides that simultaneously bind and stimulate multiple receptors Clinical Implications With retatrutide, a triple receptor agonist that has been studied in clinical trials for obesity and metabolic diseases, including type 2 diabetes and MASLD

The peptides work by interacting with the IGF-1 receptor to support processes such as cell growth, differentiation, and regeneration, which are crucial for muscle development and metabolic efficiency

This is most commonly attributed to weight loss and reduced body fat insulation rather than a direct pharmacological effect