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Groups of BALB/c mice were challenged intranasally with 110 7 CFU of the wt, gpoA , and wt gpoA + strains individually

doi: 10.1038/nature18309 22 ZhaoSJangCLiuJUeharaKGilbertMIzzoLet al

Monitor renal function and ensure adequate hydration, particularly during dose escalation Side Effect Management Gastrointestinal side effects are the most common reason for discontinuation of this medication class