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Here, we reviewed the therapeutic effects and possible mechanisms of action of GLP-1RAs in the nervous, cardiovascular, and endocrine systems and their correlation with metabolism, tumours and other diseases

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For example, a patient taking once-daily long-acting (basal) insulin and starting a weekly GLP-1RA could be instructed after the second injection of dulaglutide/ semaglutide, every time your fasting glucose level is below [target] mmol/L, reduce your [insulin brand] insulin dose by [10% of dose] units

In fact, it affects virtually every metabolic path in the body

It may reduce sympathetic activity, which is often elevated in people with hypertension