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5-Amino-1MQ is a first-in-class small molecule inhibitor designed to target Nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that acts as a master regulator of the cellular "metabolic drain."

96 In addition to eliminating neuronal synapses, the removal of perineuronal nets (PNNs) by microglia is also involved in the pathogenesis of AD

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PMID 30724228

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