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The silencing of PGC-1 mediated by si-PGC-1 LNP not only plays a crucial role in cancer cell energy metabolism but also impacts tumor metastasis, providing new perspectives for understanding bladder cancer metastasis mechanisms

An unexpected finding of Chen et al.'s study was that G6PD knock-out animals have impaired folate metabolism since methylenetetrahydrofolate reductase (MTHFR) converts 5,10-methylenetetrahydrofolate to 5-methyl-tetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine [125]

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After the fat has been metabolized in the mitochondria and has generated the energy ATP, Carnitine is again needed to remove the waste product from the mitochondria

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