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Similarly, symptoms of gallbladder diseasesuch as pain in the right upper abdomen, fever, or yellowing of the skin or eyesrequire prompt medical review, as GLP-1 receptor agonists have been associated with an increased risk of gallstones

This suggests that, from a regulatory and pharmacological standpoint, the combination is considered acceptable

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As of April 2026, the FDA formally proposed - in a Federal Register notice - removing semaglutide, tirzepatide, and liraglutide from the 503B outsourcing bulks list

Trade-offs: The benzyl alcohol contraindicates use in neonates (documented in Pfizer prescribing information neonatal gasping syndrome was the historic concern)