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TLR4 receptor inhibition reduces MCP-1 secretion from sUA renal tubular cells (118)

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Also, vitamin D and metformin reversed T2DM-induced increase in serum creatinine and urea and renal lactate, LDH, and oxido-inflammatory response

FIGURE 3 4 Mitochondrial ROS production, clearance, and dysregulation 4.1 Generation of mitochondrial ROS Mitochondria are essential organelles responsible for ATP production via oxidative phosphorylation (OXPHOS), and they play central roles in calcium handling, apoptosis, biosynthetic metabolism, and redox regulation