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These engineered cells express the human glucagon-like peptide-1 receptor (GLP-1R) and a CRE-binding protein (CREB)-inducible SEAP reporter gene

[ Figure 1

In lung cancer tissues, the expression of IGFBP-4 was markedly lower than that in normal tissues adjacent to the cancer, but the expression of COX-2 was greater in lung cancer tissues

However, the drink plenty of water caveat is crucial, as dehydration can exacerbate constipation from GLP-1 drugs, especially with the appetite-suppressing effects potentially leading to reduced fluid intake for those taking GLP-1 for weight management