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Once gp120 binds to CD4, the chemokine receptor type 4 (CXCR4) is expressed, allowing gp120 to bind to it, which is followed by a fusion of gp41 with CXCR4

Some people just dont absorb it very well due to a lack of a substance called intrinsic factor a protein produced in the stomach that binds to B12, helping it to be absorbed into the blood