In the case of alcohol the mechanism is well described: ethanol metabolism involving the CYP2E1 enzyme releases free radicals, and these reduce the level of reduced glutathione in the liver (Lieber, Drug Metabolism Reviews 2004, PMID 15554233)
It is composed of three amino acids (protein building blocks): cysteine, glutamic acid, and glycine
Wang et al., 2021), while caspase-3 induces Gasdermin E (GSDME) cleavage (Wang et al., 2017)
It is accepted that bacterial infection induces sepsis via the production of endotoxins and the process is maintained by the inflammatory cascade and oxidative mechanisms that, once activated, operate independently from the presence of pathogens 103
If you have asthma and are considering taking glutathione supplements, consult with your healthcare professional to determine the best course of action for your specific health needs