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(Erstad 2022) Valproic acid may be especially effective in myoclonic status epilepticus

For GLP-1 antagonist treatment, mice were injected with exendin-(939) amide (Ex-9) (2081, R&D Systems) at a dose of 25 nmol/kg/day or vehicle (PBS) for 5 days

Zwingmann C, Butterworth R

With this in mind, the resistance of small molecule agonists or antagonists appears due to reduction of the binding affinity by mutation of target, PROTAC is likely to overcome this challenge