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Annu Rev Nutr 24: 579-596

Statistical analyses were performed by SPSS23.0 (SPSS Inc., Chicago, USA) and GraphPad Prism 7 (GraphPad Software, San Diego, USA)

Reports across the 1980s described DSIP modulation of responses to morphine, amphetamine and barbiturates in rodents, with a profile generally interpreted as opioid-system modulation rather than direct opioid-receptor binding (Graf & Kastin, 1984)