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The article traces it to the drug class's core mechanism: slowed gastric emptying and altered gut motility keep food and gas in the stomach longer, creating pressure and distension
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NAD + has an essential role as a source of ADP-ribose for three main classes of enzymes, each releasing nicotinamide as a byproduct: 1) mono- and poly-ADP-ribosyltransferases (ARTs, formerly PARPs) utilize ADP-ribose to modify proteins post-translationally and get activated during DNA repair processes 8
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