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Reducing overall toxic burden is important for both partners in supporting optimal fertility and pregnancy outcomes

The main challenge is potential irritation at very high concentrations (above 20%), but formulations between 10-20% are generally safe and effective

Future exploratory work should examine whether this clinal response in folate homeostasis is an adaptive component within current models of the evolution of skin pigmentation (the vitamin D-folate hypothesis)

Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis

RA: Writing review & editing, Supervision