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A lot of menopausal weight gain is due to changes and shifts in hormones, specifically with a drop in estrogen, Shah says

Along with monitoring your glucose levels, TIR may impact your customized plan for maintenance

The mechanism is sound: restore GHRH signaling, raise GH and IGF-1, shift fat metabolism toward lipolysis in the visceral depots, and improve downstream metabolic markers

The general dosing approach is: Starting dose: 8 mg once daily, taken at the same time each day if possible First step up: After at least 30 days, the dose may be increased to the next level (commonly 2.5 mg) Continued titration: Further increases happen at intervals of at least 30 days, moving up through 5.5 mg, 9 mg, and 12 mg as tolerated Maintenance dose: The maintenance dose is decided by your specialist based on how you tolerate the medication and the response you are seeing The tablet should be swallowed whole, not crushed, broken, or chewed

Ongoing patient surveillance and risk-benefit assessments are essential for clinical use of traditional GLP-1s