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Studies suggest potential improvements in blood pressure, lipid profiles, and cardiovascular outcomes, making it a holistic solution for overall health

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GHD also contributes to the alteration of body composition and weight gain, with decreased lean mass, increased FM, mainly truncal FM with increase waist/hip ratio, scarce muscle tone and strength, reduced energy expenditure, and exercise tolerance [45,46,47]

However, there is still a lack of in vivo understanding of many processes at neural barriers, making robust validation of model systems to be associated with noticeable difficulties