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doi: 10.1016/j.neurobiolaging.2010.02.014 173 WangXHYangWHolscherCWangZJCaiHYLiQSet al

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The most common psychiatric disorders were anxiety (in 0.7% to 4.4% of semaglutide patients versus 1.0% to 3.9% of placebo patients), insomnia (in 1.7% to 4.7% of semaglutide patients versus 1.0% to 4.9% of placebo patients), and depression (in 0.5% to 3.9% of semaglutide patients versus 1.2% to 3.0% of placebo patients)

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The honest answer is that no clinically validated human dosing protocol exists