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10.1038/s41573-025-01183-8 16 FangZ.ChenS.PickfordP.BroichhagenJ.HodsonD

-Glutamylcysteine synthetase is composed of a heavy or catalytic (GCS-HS) and a light or modifier (GCS-LS) subunit

For the 60 mg over-the-counter dose available in Alli, the Alli SmPC and PIL indicate that users may lose more weight than with diet and exercise alone, though the absolute additional benefit at this lower dose is more modest than at 120 mg

Rheumatology 44 , 860 (2005)

Whether your goal is 10 pounds or 70 pounds, the strategy depends on your starting BMI, medical history, dose titration, and consistency with follow-up