While some specialists may measure serum DAO activity or plasma histamine levels, these tests have limited sensitivity and specificity and are not validated for confirming the diagnosis
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Additionally, hedysarum polysaccharide, derived from Radix Hedysari , ameliorated DPN by activating the Keap1/Nrf2 signaling pathway, further supporting the role of Nrf2 activation in managing OS-related complications in diabetes (He et al., 2022)