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"Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1"

Secondly, the clinical trial was conducted with an open-label design, which may introduce performance and detection bias, as the lack of blinding for participants and clinicians could influence subjective endpoints such as treatment adherence and data recording

However, for both monotherapy of MEK inhibitor and combined treatment of BRAF and MEK inhibitors, acquired resistance through reactivation of the MAPK pathway can restrict their therapeutic efficacy (141)

clinical trials show 5-15% body weight reduction on average

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