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doi: 10.1038/s41586-019-1705-2 40 DollSFreitasFPShahRAldrovandiMda SilvaMCIngoldIet al

IL-6 modulation (palmitoyl tetrapeptide-7): The second Matrixyl 3000 component, Pal-GQPR, is studied for its effects on IL-6 and other inflammatory mediators in skin aging models

Itaconate is a metabolite synthesized by cis-aconitate decarboxylase and is produced by lipopolysaccharide-activated macrophages through the diversion of cis-aconitate from the tricarboxylic acid cycle

Given its dose-dependent effectiveness and safety, NAC is a strong candidate for repurposing as a clinical treatment for liver disease (61)