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However, preclinical studies demonstrate therapeutic effects with once-daily or even less frequent administration, suggesting tissue distribution, receptor binding, or cellular signaling effects extend beyond plasma clearance

P.MeisterA

Schiaffino, S

Vitamin B-12 can't be made by our body and must come through diet, supplements, or infusions for instant effect

He continued to say that for people with B12 deficiency, parenteral supplementation (ie not through the mouth/digestive system) therefore is a useless and expensive treatment, and if you still want it the NHS should not pay for it, you should pay for it yourself