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In the NHS, semaglutide for weight management is provided via specialist services and usually for a limited duration as per NICE guidance (TA875)

Smith KR, Granberry M, Tan MCB, Daniel CL, Gassman NR

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In people with hyperthyroidism, excess thyroid hormone accelerates metabolism and can mask appetite suppression effects, meaning tirzepatide's impact on weight loss may appear delayed compared to patients with normal thyroid function