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This cursory review of cerebrospinal fluid metabolomics results is limited because of the diversity of targeted and untargeted mass spectrometry results that cannot be directly compared between studies or to the Biocrates method used here

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Efficient sample cleanup is a critical step in LCMS/MS bioanalysis of peptide therapeutics, where plasma proteins and endogenous phospholipids can contribute to matrix effects, ion suppression, and chromatographic interferences

Abrahamsson N, Engstrm BE, Sundbom M, Karlsson FA