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5 Enhanced antitumor strategies via COF-mediated remodeling of the tumor microenvironment The design flexibility of COFs allows them to be precisely engineered with enzyme-mimicking activities, actively reversing the immunosuppressive TME, thereby enhancing antitumor immunotherapy

Future directions Available research on AOX therapy is surrounded by several limitations and biases, including small sample sizes, heterogenous patient populations and inclusion criteria, poor study designs, and inconsistent reporting of clinical outcomes

Busch K, Thimme R

However, due to the discrepancies between the Woods lamp technique and in vivo histopathological results in melasma classification, reflectance confocal microscopy (RCM) was introduced (Liu et al., 2011)