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The Journal of Clinical Endocrinology & Metabolism , 102(7), 23492355

Effects on curvature and plaque were not evaluated in the randomized phase but curvature improvements were noted in 23% of patients and plaque reductions in 47% of patients in the open-label phase

Loss-of-function variants have been associated in research with reduced pigmentation, increased ultraviolet sensitivity, and diminished efficiency of DNA repair processes

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