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DSIP is a nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated from rabbit cerebral venous blood during slow-wave sleep induction by Monnier et al

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Step 1: Exposure to UV radiation generates Reactive Oxygen Species (ROS) [3] Step 2: High levels of ROS induce oxidative stress, which leads to Tyrosinase activation, the enzyme responsible for melanin synthesis

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