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Studies by the Calorie Restriction Society, a group of people who chose to limit their calorie consumption with the intention of extending their life span, included adult men and women (mean BMI, 19.6

Collectively, these data imply a clear mortality benefit associated with the use of metformin

Circulation 106 , 653658 (2002)

These Authors failed to evidence significant changes in indexes of insulin resistance and speculated that other classical effects of GLP-1 RA, such as suppressed glucagon secretion, with consequent reduced hepatic glucose production, could have been involved in the improvement in glucose metabolism and ectopic fat deposition [54]