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Additionally, the interplay between OA and body mass index has been explored in relation to leptin promoter methylation in Taiwanese adults [95]

doi: 10.2174/0929867323666151127201732 580 MendonaRDCarvalhoNCMartin-MorenoJMPimentaAMLopesACSGeaAet al

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CagriSema treatment resulted in substantially greater and clinically meaningful weight loss (-20.4%) than semaglutide alone (-14.9%), cagrilintide alone (-11.5%), or placebo (-3.0%), a finding consistent with at least partial additivity, although the study design does not permit a formal assessment of additive or synergistic effects