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The estimate of liver necrosis is rather small, less that 0.05% damage, and this may be sufficient to account for the elevation of ALT observed by Watkins et al.[38], and the absence of symptoms of liver disease after chronic usage

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In MCAS, mast cellswhich line the blood vessels, nerves, and mucosal tissuesbecome hyper-responsive, inappropriately releasing massive amounts of histamine, cytokines, and other inflammatory mediators in response to minor environmental or internal triggers

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ANDREW HUBERMAN: Does that square with your experience