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Semaglutides are a weekly injection that patients can do in the comfort of their own home

GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide) and the GIP/GLP-1 dual agonist tirzepatide modulate appetite, satiety, and gastric emptying, documented across STEP (semaglutide, NEJM 2021), SURMOUNT (tirzepatide, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)

Researchers and clinicians consistently describe it as non-linear a pattern of losses, flat stretches, and occasional small upticks that, over months, tends to average out to a downward trend

[1] [2] While these often improve after the first few weeks, persistent symptoms may require dose adjustment, slower titration, or additional supportive measures

But numbers like these only matter if the comparison is fair