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The impact of age-related dysregulation of the angiotensin system on mitochondrial redox balance

Holland WL, Bikman BT, Wang LP, Yuguang G, Sargent KM, Bulchand S, Knotts TA, Shui G, Clegg DJ, Wenk MR, Pagliassotti MJ, Scherer PE, Summers SA (2011) Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice

Although the inhibition of mTOR stimulates autophagy, these therapeutic observations are somewhat surprising since mTOR signaling is the master regulator of many survival processes and thus its inhibition should evoke harmful responses

Regulatory status is a hard fact independent of mechanistic promise

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