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Tirzepatide, while FDA-approved for weight loss, was not included because the recency of that approval limited the data available for analysis

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Along with weight, clinicians often recommend tracking appetite, portion sizes, and how full you feel after meals

Developed through systematic structure-activity relationship studies, it was engineered to optimize GH-releasing potency while minimizing effects on cortisol and prolactin secretion, a selectivity profile that distinguishes it from earlier, less refined GHRPs such as GHRP-2 and GHRP-6