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Mol Cell Endocrinol 487:4553 Dschietzig T et al (2003) Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kappaB

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We're going to compare adolescents and adults and bring in the science of brain plasticity

Trial FLOW (Perkovic et al., NEJM 2024) Design Phase 3 / event-driven Population 3,533 adults with T2D and CKD Key result 24% reduction in kidney disease progression and CV death (HR 0.76