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CCT-deficient B cells stimulated with LPS triggered early activation of the unfolded protein response (UPR)-mediated splicing of Xbp-1, and impaired class switching, reducing antigen-specific IgG1 production while increasing IgM secretion upon antigen challenge (104) ( Figure 3 )

5xFAD mice start to develop visible A deposits as early as 2 months of age, consistent with their dramatically accelerated A1-42 production