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Ethics declarations Ethics approval and consent to participate The study was approved by the ethical review board of the Animal Ethics Committee of Central South University (CSU-2022-0116)

Curcumin and its derivatives: Their application in neuropharmacology and neuroscience in the 21st century

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Circadian Rhythm and Pineal Biology: Epitalon Dominant Epitalons restoration of pineal AANAT activity and melatonin output is its most unique biological niche

Important note: Although oral therapy is very effective, the treatment of a severe deficiency with pronounced neurological symptoms should always be carried out in close consultation with a doctor