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The primary cause of hot flashes relates to declining estrogen levels during the menopausal transition and postmenopausal period

doi: 10.1186/s12985-022-01814-1

Tirzepatide for diabetes (Mounjaro) uses the same dose range as for weight loss (up to 15 mg)

Rimonabant, the first selective central cannabinoid (CB1) receptor antagonist, was not approved by the FDA because of concerns regarding psychiatric adverse events including depression, anxiety and suicidal ideation [20]