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Upon activation, the receptor initiates complex signaling networks through three primary pathways with distinct temporal and spatial characteristics (Figure 1) [15,16]

Proc Natl Acad Sci USA 96(7):39813986

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Specifically, these two regulate the cells entry into the proliferative phase (division)

Incorporation of the K1269A COPI binding site mutation into full-length S protein caused, at most, only a small increase in the cell surface expression (Fig