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Akt is activated as a result of insulin or insulin growth factor signaling and plays a vital role in GLUT4 translocation 20

While semaglutide is not specifically approved for use in patients with high cortisol levels, it may offer some potential benefits, particularly in terms of weight loss and blood sugar control

They are particularly useful for individuals with pernicious anemia or other conditions that impair Vitamin B12 absorption through the digestive tract

Funding This work was supported by the Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine (to HL) and the Albert B