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For anxiety and depression that co-occur with diabetes and obesity, semaglutide and, to a lesser extent, liraglutide might be useful dually effective therapeutic options, the authors concluded

34 It's advisable to increase fiber intake gradually over several weeks, along with adequate fluid intake, to allow the digestive system to adapt and minimize potential side effects like gas or bloating

Clinical trials are being run on combination therapies that can help preserve muscle massa big issue for GLP-1 usersand maybe even cut back on GI symptoms

These are usually mild and fade as the body adapts

Semaglutide oral tablets (Rybelsus ), with 94% homology to human GLP-1, were approved in 2019 as the first GLP-1R agonists for oral administration (Ke et al., 2024) (Table 2)