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And a fatty acid chain (a C18 modification) anchors the molecule to albumin in the bloodstream, which is what gives semaglutide its long half-life

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however, patients taking anticoagulants (such as warfarin, apixaban, or rivaroxaban), antiplatelet agents (including aspirin or clopidogrel), or non-steroidal anti-inflammatory drugs (NSAIDs) have an inherently increased bleeding risk

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