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[19] [21] The compounds targeted in this manner by GSTs encompass a diverse range of environmental or otherwise exogenous toxins, including chemotherapeutic agents and other drugs, pesticides, herbicides, carcinogens, and variably-derived epoxides

Multiple mechanisms appear to play a role in this relationship

Oxidative Medicine and Cellular Longevity, 2017 , 7265238.

4.1.1 Trans-synaptic transport of -synuclein Misfolded -synuclein aggregates in the ENS, potentially caused by gut inflammation, dysbiosis, or environmental pollutants, can be absorbed by enteric neurons and mucosal epithelial cells

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