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As a central transcription factor, NRF2 influences this cell death mode by inducing a variety of genes including SLC7A11, GPX4, FSP1, NQO1, HMOX1, ferritin heavy chain 1 (FTH1), HECT and RLD domain-containing E3 ubiquitin protein ligase 2, and vesicle-associated membrane protein 8 in hepatocellular carcinoma and ovarian cancer cells [85, 86]

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Cell Metab 2008;8:212223 [DOI] [PubMed] [Google Scholar] 76

And its interesting with biosimilars because when I first heard of them, I had that uncomfortable feeling that many patients have where its like: my number one priority is feeling good, and thats how I feel on the drug that I have now

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