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Despite this broad therapeutic interest, certain domainsparticularly skeletal muscle biology and neurodegenerationillustrate a recurring translational mismatch between mechanistic signaling effects and clinical functional outcomes

NR, not reported

Plaintiffs had also raised concerns that the early discovery process could put the NAION litigation out of sync with Marstons separate GLP-1 stomach paralysis MDL, which involves thousands of cases and is proceeding toward its own independent bellwether process

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