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10.1146/annurev.nutr.18.1.39 Ann Rev Nutr

Collectively, these recent contributions argue that future GSH-centric redox sensing and nanomedical approaches should (i) incorporate organelle targeting (especially mitochondria) to exploit subcellular redox heterogeneity, (ii) embed analyte-responsive activation into both therapeutic and imaging components, (iii) combine biochemical sensing with optical or thermal engineering for spatiotemporal control, and (iv) favor clinically translatable carriers (e.g., PLGA) for delivery

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Where Meto fits in this conversation At Meto, the goal isnt to chase trendsits to match tools to physiology

The initial side effects often become less intense or may disappear altogether